Why does daptomycin cause eosinophilic pneumonia?


Why does daptomycin cause eosinophilic pneumonia?

Although the mechanism of daptomycin-induced eosinophilic pneumonia is unknown, some have speculated that daptomycin may bind to human surfactant and accumulate in the alveolar space causing injury to the epithelium with resulting inflammation [7, 8].

Why can’t daptomycin be used in pneumonia?

Daptomycin should not be used to treat pneumonia. This is due to the fact that daptomycin is inhibited by surfactant (Silverman et al 2005).

Does daptomycin cover pneumonia?

Daptomycin provides great coverage for gram positive cocci. Shortly after its approval, concerns were raised regarding the pulmonary side effects of daptomycin and potential development of acute eosinophilic pneumonia (AEP) secondary to daptomycin therapy. About 35 cases were reported in the literature.

Can daptomycin cause lung problems?

The precise mechanism for daptomycin-induced lung injury is unknown but is believed to be related to daptomycin binding to pulmonary surfactant culminating in epithelial injury [2]. Daptomycin-induced AEP is seen in the elderly, receiving doses in the range of 4-10 mg/kg/day.

Is eosinophilic pneumonia an interstitial lung disease?

AEP is classified as a form of eosinophilic lung disease, a large group of interstitial lung diseases. AEP is different from chronic eosinophilic pneumonia (CEP), which is marked by slower progression, lack of progression to acute respiratory failure, frequent relapses and is often associated with asthma.

Can daptomycin cause C diff?

Adverse Effects It is important to note that prolonged use of daptomycin can develop a superinfection such as Clostridium difficile-associated diarrhea (CDAD) and pseudomembranous colitis. The incidence of CDAD has been observed greater than two months after treatment with daptomycin.

What are the side effects of daptomycin?

Nausea, vomiting, constipation, diarrhea, headache, dizziness, trouble sleeping, increased sweating, or pain/redness/swelling at the injection site may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Is daptomycin a strong antibiotic?

Daptomycin (Cubicin) is an injectable antibiotic used to treat serious bacterial infections of the skin and underlying tissues and infections that have entered the bloodstream. Daptomycin (Cubicin) is usually used for complicated and serious infections since it is a strong antibiotic.

Is eosinophilic pneumonia curable?

Eosinophilic pneumonia may be mild, and people with the disease may get better without treatment. For acute eosinophilic pneumonia, a corticosteroid such as prednisone is usually needed. In chronic eosinophilic pneumonia, prednisone may be needed for many months or even years.

How do you get eosinophilic pneumonia?

Known causes of eosinophilic lung disease include allergic bronchopulmonary aspergillosis and related disorders and exposure to parasitic infections, drugs, or certain toxic substances. Systemic disorders that cause eosinophilic pneumonia include Churg-Strauss syndrome and Langerhans cell histiocytosis.

Is daptomycin a high risk drug?

Elderly patients are at an increased risk of daptomycin toxicity due to age-related changes in renal function or factors that may enhance the exposure to the medication. However, no dosage adjustments are recommended for patients with a creatinine clearance greater than 30 mL/min.

When should you not take daptomycin?

2.0 Daptomycin should not be used for empiric therapy of non-life-threatening infections where there is little evidence that MRSA or VRE are infecting or colonizing microorganisms. 4.0 Daptomycin should not be used for inpatients for the simple convenience of once- daily dosing.