Who should not take danazol?
Danazol must not be taken by women who are pregnant or who could become pregnant. Danazol may harm the fetus. You will need to have a negative pregnancy test before you begin taking this medication. Start taking this medication during your menstrual cycle to be sure you are not pregnant.
What are the most common adverse reactions of the prescribed medications?
Allergic drug reactions account for 5 to 10% of all adverse drug reactions. Any drug has the potential to cause an allergic reaction. Symptoms of adverse drug reactions include cough, nausea, vomiting, diarrhea, and headaches. Skin reactions (i.e. rashes, itching) are the most common form of allergic drug reaction.
What are some common adverse effects associated with medications?
Common minor side effects of prescription drugs:
- Diarrhea.
- Dizziness.
- Drowsiness.
- Fatigue.
- Heart issues (palpitations, irregular heartbeats)
- Hives.
- Nausea and vomiting.
- Rash.
Is danazol a black box warning?
Danazol is a estrogen antagonist, endocrine metabolic agent that is FDA approved for the treatment of endometriosis, fibrocystic breast disease, hereditary angioedema. There is a Black Box Warning for this drug as shown here. Common adverse reactions include acne, weight gain.
Can danazol cause high blood pressure?
In view of the growing indications for therapy with danazol, increasing numbers of susceptible patients may be at risk of having drug-induced hypertension develop. We, therefore, recommend that blood pressure be routinely monitored in patients receiving this drug.
What are the side effects of Clomid?
Clomid side effects
- Mood swings, psychological / emotional side effects.
- Hot flashes.
- Abdominal discomfort.
- Visual disturbances.
- Ovarian cyst formation.
- Nausea.
- Thinning of the uterine endometrial lining.
- Reduced production of cervical mucous – this can lower fertility (bypassed by insemination)
What is an adverse reaction to medication?
Side effects, also known as adverse reactions, are unwanted undesirable effects that are possibly related to a drug. Side effects can vary from minor problems like a runny nose to life-threatening events, such as a heart attack or liver damage.
What is the most common type of adverse drug event?
An allergic reaction is the most common type of antibiotic-associated adverse drug event, so minimizing unnecessary antibiotic use is the best way to reduce the risk of adverse drug events from antibiotics.
Does danazol cause edema?
Significant side effects from danazol were reported by 85% of the patients. The major side effects were weight gain, edema, decrease in breast size, oily skin, hirsutism, and deepening of the voice.
Is danazol a steroid?
Danocrine (danazol) is a synthetic steroid with multiple and diverse biologic effects. It exerts these effects by binding to steroid transport proteins in the circulation and to specific receptors in target tissues. Centrally, danazol inhibits gonadotropins, suppressing gametogenesis and steroidogenesis.
What are the side effects of discontinuing danazol?
SIDE EFFECTS. Although cyclical bleeding and ovulation usually return within 60-90 days after discontinuation of therapy with danazol capsules, persistent amenorrhea has occasionally been reported. Flushing, sweating, vaginal dryness and irritation and reduction in breast size, may reflect lowering of estrogen.
What are the side effects of danazol in hypoparathyroidism?
Danazol can increase the calcemic response to synthetic vitamin D analogs in primary hypoparathyroidism. The risk of myopathy and rhabdomyolysis is increased by concomitant administration of Danazol with statins such as simvastatin, atorvastatin and lovastatin.
When should I Call my doctor if I am taking danazol?
Tell your doctor if you have or have ever had liver disease. If you experience any of the following symptoms call your doctor immediately: yellowing of the skin or eyes, pain in stomach area, extreme tiredness, or unusual bleeding or bruising. Danazol can cause increased pressure of the fluid inside the skull.
What is the mechanism of action of danazol?
This suppression is probably a combination of depressed hypothalamic-pituitary response to lowered estrogen production, the alteration of sex steroid metabolism, and interaction of Danazol with sex hormone receptors. The only other demonstrable hormonal effect is weak androgenic activity.