Which SSRI causes least QT prolongation?


Which SSRI causes least QT prolongation?

Based on current literature, fluoxetine, fluvoxamine, and sertraline appear to have similar, low risk for QT prolongation, and paroxetine appears to have the lowest risk.

Does risperidone increase QT?

Risperidone induces QT prolongation. ECG at the admission was normal and the corrected QT value (QTc; according to the Bazett formula) was not prolonged under the treatment of aripiprazol (20 mg/day), haloperidol (3 mg/day) and escitalopram (20 mg/day). Subsequently, the QTc value was monitored regularly.

Does olanzapine prolong QT?

Conclusion: Results of these analyses suggest that olanzapine, as therapeutically administered to patients with schizophrenia and related psychoses, does not contribute to QTc prolongation resulting in potentially fatal ventricular arrhythmias.

Does Abilify prolong QT interval?

No thorough QT (TQT) study with aripiprazole was found. The meta-analysis revealed that the mean ΔQTc interval was decreased with aripiprazole and QTc prolongation risk was lower compared with placebo and active controls.

Which antipsychotic is safest for QTc prolongation?

The sensitivity analyses also showed the superiority of quetiapine when the baseline QTc intervals were prolonged. Conclusions: Decision analysis suggests that quetiapine is the optimal antipsychotic drug for the treatment of patients with delirium and prolonged baseline QTc intervals.

Does Wellbutrin cause QT prolongation?

Other modern antidepressants, including fluoxetine, paroxetine, and sertraline, showed no QT-interval prolonging effect, whereas bupropion was actually associated with shortening of the QT interval.

Which antipsychotics prolong the QT interval?

Typical (First-Generation) Antipsychotics: The typical antipsychotics associated with the greatest risk of QTc prolongation are thioridazine, haloperidol, chlorpromazine, and pimozide.

Which antipsychotic is best for QTc?

Does Prozac prolong QT?

A variety of drugs have been identified as the cause of QT prolongation and of risk of life-threatening ventricular arrhythmias. This association is recognized for selected psychotherapeutic agents such as phenothiazines and tricyclics.

Which psychotropics carry the greatest risk of QTc prolongation?

There are limited data that selective serotonin reuptake inhibitors (SSRIs) as a class are linked to QTc prolongation; citalopram appears more likely than others to induce this phenomenon. Among antipsychotics, thioridazine remains the agent most associated with QTc prolongation; intravenous haloperidol also appears to carry an increased risk.

Which medications shorten the QT interval?

having a family history of TDP

  • being female
  • being older
  • taking certain medications
  • Which antidepressants cause QT prolongation?

    – Use of >1 QT prolonging medicine – Medicines that inhibit the metabolism of another QT prolonging medicine – Medicines that cause electrolyte abnormalities or may cause renal or hepatic dysfunction

    Which antipsychotic least QTc?

    •Nearly all antipsychotics prolong QTc, but the degree of prolongation differs substantially among agents. •Haloperidol –In oral form, haloperidol leads to QT prolongation that is similar to aripiprazole, quetiapine, and asenapine. –Intravenous form may lead to higher risk of QTc prolongation, with some caveats.