What is the penumbra in stroke?

2020-08-06

What is the penumbra in stroke?

“Penumbra” is the term used for the reversibly injured brain tissue around ischemic core; which is the pharmacological target for acute ischemic stroke treatment (Astrup et al. 1981a). The goal to treat ischemic stroke is to salvage the penumbra as much and early as possible.

What causes the penumbra stroke?

The penumbra region typically occurs when blood flow drops below 20 mL/100 g/min. At this point electrical communication between neurons fails to exist. Cells in this region are alive but metabolic pumps are inhibited, oxidative metabolism is reduced but neurons may begin to depolarize again.

Why is ischemic penumbra important?

The concept of the ischemic penumbra is an important one for both basic investigators of cerebral ischemia and for clinicians who treat stroke patients.

Is there penumbra in hemorrhagic stroke?

Brain PET imaging in traumatic hemorrhage has revealed that an upregulation of glucose uptake occurs in the penumbra. This increase in glucose use, termed hyperglycolysis, can be detected up to 5 days after the onset of hemorrhage.

What is the most common cause of embolic stroke?

The most common cause of Embolic stroke is the movement of a blood clot through an artery and clogging it in a narrow place. A blood clot is blood that is mainly made up of platelets.

What does the penumbra do?

The Moon’s penumbra causes partial solar eclipses, and the Earth’s penumbra is involved in penumbral lunar eclipses. The penumbra is a lighter type of shadow. Like any other opaque objects illuminated by a light source, the Moon and the Earth cast shadows into space as they block the sunlight that hits them.

What are complications of TPA?

Complications related to intravenous r-tPA include symptomatic intracranial hemorrhage, major systemic hemorrhage, and angioedema in approximately 6%, 2%, and 5% of patients, respectively.

What happens during a hemorrhagic stroke?

A hemorrhagic stroke occurs when blood from an artery suddenly begins bleeding into the brain. As a result, the part of the body controlled by the damaged area of the brain cannot work properly.

What are 3 possible treatments of an ischemic stroke?

Ischemic stroke

  • Emergency IV medication. Therapy with drugs that can break up a clot has to be given within 4.5 hours from when symptoms first started if given intravenously.
  • Emergency endovascular procedures. Doctors sometimes treat ischemic strokes directly inside the blocked blood vessel.

How can you tell the difference between ischemic and hemorrhagic stroke?

An ischemic stroke occurs when a blood vessel supplying the brain becomes blocked, as by a clot. A hemorrhagic stroke occurs when a blood vessel bursts, leaking blood into the brain.