What is the mechanism of action of lincomycin?


What is the mechanism of action of lincomycin?

Mechanism Of Action Lincomycin inhibits bacterial protein synthesis by binding to the 23S RNA of the 50S subunit of the bacterial ribosome. Lincomycin is predominantly bacteriostatic in vitro.

What is the mechanism of action of clindamycin?

Clindamycin works primarily by binding to the 50s ribosomal subunit of bacteria. This agent disrupts protein synthesis by interfering with the transpeptidation reaction, which thereby inhibits early chain elongation.

Is lincomycin bacteriostatic or bactericidal?

Lincomycin and its semi-synthetic chlorinated derivative clindamycin are widely used in clinical practice. Both antibiotics are bacteriostatic, inhibiting protein synthesis in sensitive bacteria; however, at higher concentrations, they may be bactericidal.

What is the mechanism of action of macrolides?

The mechanism of action of macrolides revolves around their ability to bind the bacterial 50S ribosomal subunit causing the cessation of bacterial protein synthesis.

What is the function of lincomycin?

Lincomycin is an antibiotic that is used to treat severe bacterial infections in people who cannot use penicillin antibiotics. Lincomycin is used only for a severe infection. This medicine will not treat a viral infection such as the common cold or flu.

Which drug acts by inhibiting the protein synthesis of the bacteria?

This drug acts to inhibit bacterial protein and DNA synthesis. Puromycin is an antibiotic that prevents bacterial protein translation….Protein Synthesis Inhibitors.

Drug Target Type
Streptomycin 23S ribosomal RNA target
Streptomycin Bacterial outer membrane target
Streptomycin Cytoplasmic membrane target
Kanamycin 30S ribosomal protein S12 target

What is the mechanism of action of fluoroquinolones?

1. Mechanism of action. Fluoroquinolones act by inhibiting two enzymes involved in bacterial DNA synthesis, both of which are DNA topoisomerases that human cells lack and that are essential for bacterial DNA replication, thereby enabling these agents to be both specific and bactericidal.

What side effect is typical for lincomycin?

nausea, vomiting, swollen or painful tongue; vaginal itching or discharge; mild itching or rash; ringing in your ears; or.