What is HLA computer?
The High Level Architecture (HLA) is a standard for distributed simulation, used when building a simulation for a larger purpose by combining (federating) several simulations.
How many HLA variants are there?
There are three general groups of HLA, they are HLA-A,HLA-B and HLA-DR. There are many different specific HLA proteins within each of these three groups. (For example, there are 59 different HLA-A proteins, 118 different HLA-B and 124 different HLA-DR!)
What are HLA factors?
HLA genes are highly polymorphic, which means that they have many different alleles, allowing them to fine-tune the adaptive immune system. The proteins encoded by certain genes are also known as antigens, as a result of their historic discovery as factors in organ transplants.
What is NGS HLA typing?
Achieving high-resolution human leukocyte antigen (HLA) typing results with conventional methods requires multiple assays, systems, and analysis programs. HLA typing by next-generation sequencing (NGS) generates unambiguous, phase-resolved HLA typing results using a single assay, system, and analysis program.
What is meant by high level design?
High-level design (HLD) explains the architecture that would be used to develop a system. The architecture diagram provides an overview of an entire system, identifying the main components that would be developed for the product and their interfaces.
What chromosome is HLA?
The human major histocompatibility complex HLA is located on the short arm of chromosome 6. It is known to be the most polymorphic genetic system in humans. The biological role of the HLA class I and class II molecules is to present processed peptide antigens.
Why is HLA matching important?
HLA matching is important for transplant HLA matching promotes the growth and development of new healthy blood cells (called engraftment) and reduces the risk of a post-transplant complication called graft-versus-host (GVHD) disease.
What is SBT HLA typing?
Sequence-based typing (SBT) involves PCR amplification of specific coding regions of HLA genes and sequencing of the amplicons [3, 4]. The prevalence of ambiguities in HLA typing relates to the nature of polymorphisms which exists in the sequence of the major histocompatibility complex (MHC) Class I and Class II genes.