What does TRALI mean?
Transfusion Related Acute Lung Injury (TRALI)
What is the cause of TRALI?
TRALI is thought to be caused by activation of recipient neutrophils by donor-derived antibodies targeting human leukocyte antigens (HLA) or human neutrophil antigens (HNA).
What is the difference between TACO and TRALI?
Diagnostically, it remains very challenging to distinguish TACO and TRALI from underlying causes of lung injury and/or fluid overload as well as from each other. TACO is characterized by pulmonary hydrostatic (cardiogenic) edema, whereas TRALI presents as pulmonary permeability edema (noncardiogenic).
What are TRALI antibodies?
Human leukocyte antigen (HLA) class I, HLA class II, and neutrophil-specific antibodies in the plasma of both blood donors and recipients have been implicated in the pathogenesis of TRALI.
Who is at risk of TRALI?
Conclusions: The risk factors for TRALI in this study included Number of transfusions and FFP units were positively correlated with TRALI. Age, female sex, tobacco use, chronic alcohol abuse, positive fluid balance, shock before transfusion, ASA score and mechanical ventilation may be potential risk factors for TRALI.
Can you donate blood if you have TRALI?
A positive test result does not affect your health. TRALI is a condition that only affects some blood recipients. It does not affect blood donors.
What is TRALI risk?
(TRALI) TRALI is an acute complication following blood transfusion that is characterized by severe shortness of breath, often associated with fever and low blood pressure. Although rare, it is one of the most common causes of transfusion- related death.
Is TRALI preventable?
TRALI can develop within 6 hours to 72 hours of blood transfusions that are rich in plasma. Despite suspected various hypothesis, it could certainly be prevented with a careful approach in blood transfusions, especially in those who are more vulnerable for acquiring TRALI.
What is TACO syndrome?
Transfusion-associated circulatory overload (TACO) and transfusion-related acute lung injury (TRALI) are syndromes of acute respiratory distress that occur within 6 hours of blood transfusion. TACO and TRALI are the leading causes of transfusion-related fatalities, and specific therapies are unavailable.
Can I donate blood if I have HLA antibodies?
You do not need to do anything if you test positive for HLA antibodies. Your HLA antibodies pose absolutely no risk to you. You will remain eligible to donate red blood cells. Unfortunately, you will no longer be eligible to donate plasma or plasma blood products, such as platelets collected by apheresis.