What causes Tenosynovial giant cell tumor?


What causes Tenosynovial giant cell tumor?

Causes. ‌These CSF-1-producing cells attract other cells that have a CSF-1 receptor. Cells with the CSF-1 receptor are called macrophages, a type of white blood cell. When these cells join together, they form a tenosynovial giant cell tumor.

What is the most common site for giant cell tumors?

Key points about giant cell tumors Most occur in the long bones of the legs and arms. Giant cell tumors most often occur in young adults when skeletal bone growth is complete.

What is GCT Tumour?

Giant Cell tumors (GCT) are benign tumors with potential for aggressive behavior and capacity to metastasize. Although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations.

What is Tenosynovial?

Tenosynovial giant cell tumors (TGCTs) are a group of rare, benign tumors that involve the synovium, bursae and tendon sheath. Synovium is the thin layer of tissue or membrane that covers the inner surface of the joint spaces and the bursae and tendon sheaths.

Is TGCT hereditary?

Thus, inherited susceptibility to TGCT is probably polygenic and common variation is likely to make a considerable contribution.

What is synovial sarcoma?

Synovial sarcoma is a cancer that can come from different types of soft tissue, such as muscle or ligaments. It is often found in the arm, leg, or foot, and near joints such as the wrist or ankle.

Which age groups have the highest prevalence of synovial cell sarcoma?

Patients with synovial cell sarcoma are often between the ages of 15 and 35 years old; generally younger than patients with other types of soft tissue sarcomas. The most probable cellular origin is an undifferentiated mesenchymal cell.

What are the signs and symptoms of soft tissue sarcoma?

Soft tissue sarcoma. Print. Synovial sarcoma is a rare type of cancer that tends to arise near large joints, particularly the knee, in young adults. Despite its name, it typically doesn’t affect the interior of joints, where synovial tissue and fluid are located. The first sign of trouble is usually a deep-seated lump that may be tender or painful.

How fast does synovial sarcoma grow?

Synovial sarcoma generally grows slowly. While these tumors can occur in young children, they generally develop in people between the ages of 15 and 40. While synovial sarcoma can occur almost anywhere in the body, the most common locations are in the legs, arms and throat.