What are the uses of ferrocene?
Ferrocene derivatives have attracted significant interest as anticancer, antibacterial, antifungal and antiparasitic drug candidates. Discovered in the 1990s, the two most prominent derivatives, ferroquine and ferrocifen, have since been studied extensively for the treatment of malaria and cancer, respectively.
What do you mean by ferrocene?
Definition of ferrocene : a crystalline stable organometallic coordination compound (C5H5)2Fe also : an analogous compound with a heavy metal (such as chromium)
What kind of compound is ferrocene?
organometallic compound
Ferrocene is an organometallic compound of the general class metallocene with the molecular formula Fe(η5-C5H5)2. In this molecule, iron is sandwiched between two cyclopentadienyl rings in staggered conformation, as shown in Figure 6.
How is stability of ferrocene explained?
Ferrocene is an air-stable orange solid with a camphor-like odor. As expected for a symmetric, uncharged species, ferrocene is soluble in normal organic solvents, such as benzene, but is insoluble in water. It is stable to temperatures as high as 400 °C. Ferrocene readily sublimes, especially upon heating in a vacuum.
Is ferrocene paramagnetic or diamagnetic?
diamagnetic
Nickelocene and ferrocene have similar molecular structure and they are isostructural at room temperature. However, their thermal behaviors are quite different. From a magnetic viewpoint, nickelocene is paramagnetic with the electron spin S=1 (the ground state configuration 3A2g), while ferrocene is diamagnetic.
Why direct nitration of ferrocene is not possible?
Ferrocene cannot be directly nitrated or halo- genated because the reagents themselves cause oxidation of ferrocene to the ferricinium ion (4, 5, 6).
What is ferrocene how it is prepared in laboratory?
Ferrocene can be prepared on a laboratory or large-scale basis by the reaction of ferrous chloride and sodium cyclopentadienide in an amine solvent. The basicity of the latter is an important factor in the yield of ferrocene obtained.
Is ferrocene a chelate?
Ferrocene-Containins Chelate Ligands.
Is ferrocene soluble in water?
Ferrocene which is categorized as an organometallic compound is insoluble in water.
What is ferrocene used for in fuel?
Ferrocene has found two interesting applications related to fuel. It is known to promote the smoke-free combustion of fuel. It also prevents knocking in the engine when used as an additive to a fuel. Ferrocene and some of its derivatives are also useful as curing accelerators for unsaturated polyester resins.
What are ferrocifens used for?
Ferrocifens are exploited for cancer applications by a French biotech, Feroscan, founded by Pr. Gerard Jaouen. Ferrocene and related derivatives are used as powerful burn rate catalysts in ammonium perchlorate composite propellant.
Does ferrocene act as a reagent in synthesis?
At the outset, it is worth noting that in many cases ferrocene acts as a reagent in synthesis, specific examples would be in the preparation of nanotubes and iron-containing nanotubes which is not reviewed here,118,119 or the vapor-phase insertion of ferrocene into zeolites. 120
What is the formula for ferrocene?
Ferrocene is an organometallic compound with the formula Fe(C 5 H 5) 2. The molecule consists of two cyclopentadienyl rings bound on opposite sides of a central iron atom. It is an orange solid with a camphor-like odor, that sublimes above room temperature, and is soluble in most organic solvents.