Does vasculitis cause eosinophilia?
Eosinophils in other vasculitides Drug-induced vasculitis can also feature prominent eosinophilia,4 and a high degree of tissue eosinophilia in biopsy-obtained samples of purpuric lesions has been proposed as a means to differentiate this condition from other forms of cutaneous small-vessel vasculitis.
Does Churg-Strauss syndrome cause eosinophilia?
Eosinophilic granulomatosis with polyangiitis (EGPA)—or, as it was traditionally termed, Churg-Strauss syndrome—is a rare systemic necrotizing vasculitis that affects small-to-medium-sized vessels and is associated with severe asthma and blood and tissue eosinophilia.
What is associated with polyarteritis nodosa?
Polyarteritis nodosa has been associated with active hepatitis B, hepatitis C, or both; therefore, the disease is more common in injection drug users. Polyarteritis nodosa is probably mediated by deposition of immune complexes.
Is eosinophilic granulomatosis with Polyangiitis an autoimmune disease?
The inflamed vessels can affect various organ systems including the lungs, gastrointestinal tract, skin, heart and nervous system. The exact cause of eosinophilic granulomatosis with polyangiitis is unknown, but it is thought to be an autoimmune disorder.
What is eosinophilic granulomatous Polyangiitis?
Eosinophilic granulomatosis with polyangiitis (EGPA, formerly Churg-Strauss Syndrome) is a disease caused by inflammation (swelling) that occurs in certain types of cells in your blood or in your tissues. Everyone who gets EGPA has a history of asthma and/or allergies. It can affect many of your organs.
What does Churg-Strauss rash look like?
Skin manifestations of Churg-Strauss syndrome include palpable purpura; a macular or papular erythematous rash; hemorrhages (petechiae to ecchymoses); and tender cutaneous or subcutaneous nodules, often from granulomas. These skin manifestations may be caused by vasculitis, eosinophil accumulation, or granulomatosis.