Can you administer diazepam intravenously?
Diazepam may be administered intravenously or intramuscularly (deep into the muscle). However, absorption following I.M. administration is slow and erratic; thus, this route of administration should be avoided if possible.
What are the contraindications of diazepam?
Who should not take DIAZEPAM?
- low amount of albumin proteins in the blood.
- alcohol intoxication.
- drug abuse.
- myasthenia gravis, a skeletal muscle disorder.
- wide-angle glaucoma.
- closed angle glaucoma.
- worsening of debilitating chronic lung disease called COPD.
How do you prepare IV diazepam?
Dissolve the diazepam and benzoic acid in the solution. Slowly add Sterile Water for Injection to a volume of 75 to 80 mL. Add the sodium benzoate and mix until dissolved; then add the sodium hydroxide solution or hydrochloric acid to adjust the pH to the range of 6.2 to 6.9.
Can IV diazepam be added to 5% glucose drip?
In general, diazepam should not be mixed or diluted with other drugs or added to IV fluids. However, if IV infusion is required, diazepam in doses up to 20mg can be added to at least 250ml of 5% dextrose or normal saline.
What do you flush IV diazepam with?
A saline flush reduced the incidence of side effects, particularly pain (P less than 0.05). ‘Barbotage’ gave the highest incidence of side effects. Saline flush is therefore recommended as a means of reducing the thrombophlebitis which may follow intravenous diazepam.
How long does IV diazepam last?
When administered intravenously, diazepam has an onset of action within 1 to 3 minutes, while oral dosing onset ranges between 15 to 60 minutes. Diazepam is long-lasting with a duration of action of more than 12 hours.
Can diazepam be diluted before IV injection?
Diazepam Injection BP should not be diluted when administered via intravenous or intramuscular injection. IMPORTANT: In order to reduce the likelihood of adverse effects during intravenous administration the injection should be given slowly (1.0ml solution per minute).
Why is diazepam given IV?
Seizure disorder, seizures, status epilepticus Most clinicians now prefer the use of IV lorazepam over IV diazepam for treatment of acute seizure activity. A longer acting anticonvulsant should be selected for maintenance treatment of seizure activity.
How do you dilute IV diazepam?
However, if in some circumstances it is necessary to administer diazepam as an infusion, it is recommended that it be diluted in dextrose 5% in water, normal saline, Ringer’s injection or lactated Ringer’s injection to a dilution of at least 1:40 and used within 6 hours or to a dilution of 1:50 and used within 24 hours …
How fast does diazepam injection work?
1 When administered via injection, valium takes just one to five minutes to take effect. When taken orally, people usually begin to feel the effects 15 to 60 minutes after ingestion. Rectal gel may be used for those who are experiencing seizures and begins working quickly after administration.