Are Megakaryopoiesis and thrombopoiesis the same?
1.2 Megakaryopoiesis and Thrombopoiesis HSCs give rise to MKs in a process termed megakaryopoiesis while MKs release platelets in a process termed thrombopoiesis.
What factors stimulates thrombopoiesis?
If there is less platelet mass present, less thrombopoietin is cleared, which causes an increase in free plasma thrombopoietin that stimulates thrombopoiesis.
What stimulates the production of platelets?
Thrombopoietin is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets. It stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets.
What stimulates the production of megakaryocytes?
Platelets are produced from pluripotent hematopoietic stem cells in bone marrow through a unique differentiation process (Kaushansky 1995). Thrombopoietin (TPO) stimulates the differentiation of stem cells to megakaryocytes by polyploidization and cytoplasmic maturation.
What is the meaning Megakaryopoiesis?
Megakaryopoiesis is the process by which bone marrow progenitor cells develop into mature megakaryocytes (MKs), which in turn produce platelets required for normal hemostasis.
What is thrombopoiesis?
Thrombopoiesis—from thrombos (Gr., clot)—refers to the production of platelets, which are small (2 to 4 µm), round to ovoid, anucleate cells within blood vessels.
What are the stages of Megakaryopoiesis?
Megakaryopoiesis is a complex process that involves the commitment of hematopoietic stem cells (HSCs) to the megakaryocyte (MK) lineage, proliferation of the progenitors, MK maturation and terminal differentiation that produces platelets.
How is thrombopoiesis regulated?
A steady-state amount of hepatic thrombopoietin (TPO) is regulated by platelet c-Mpl receptor–mediated uptake and destruction of the hormone. Hepatic production of the hormone is depicted. Upon binding to platelet c-Mpl receptors, the hormone is removed from the circulation and destroyed, which reduces blood levels.
What are the steps of thrombopoiesis?
(1) A hemocytoblast gives rise to a common myeloid progenitor cell (CMP). (2) The CMP gives rise to CFU-Meg (or CFU-Mega, the colony forming unit that leads to the formation of megakaryocytes). (3) The CFU-Meg develops into a megakaryoblast. (4) The megakaryoblast develops into a promegakaryocyte.
How does thrombopoiesis occur?
Platelets are produced during hematopoiesis in a sub-process called thromopoiesis, or production of thrombocytes. Thrombopoiesis occurs from common myeloid progenitor cells in the bone marrow, which differentiate into promegakaryocytes and then into megakaryocytes.
How is Thrombopoiesis regulated?
How does Thrombopoiesis occur?