What is a high M spike number?
Patients with a higher M spike (greater than 1.5 g/dL) or abnormal SFLC ratio are at a higher risk of disease progression.
What is considered a high level of M protein?
High levels mean the disease is more advanced and may indicate a poor prognosis. The presence of any M spike is abnormal and shows the presence of an abnormal clone of plasma cells. If the amount of protein is ≥30 g/L and/or there are other disease symptoms, the patient may have myeloma.
What is high risk multiple myeloma?
The high-risk features include patient-specific factors such as old age, poor performance status and comorbidities; clinical features such as primary plasma cell leukemia and extramedullary disease; disease-specific biologic features such as deletion 17p, t(4;14) and high-risk gene expression profiling signatures.
How high is total protein in multiple myeloma?
Biochemical profile of patients with multiple myeloma
| Parameter | Mean ± SD |
|---|---|
| Total protein (gm/dL) | 8.08 ± 2.3 |
| Albumin (gm/dL) | 3.4 ± 0.75 |
| Calcium (mg/dL) | 9.4 ± 1.5 |
| Creatinine (mg/dL) | 2.9 ± 2.1 |
What are the signs of multiple myeloma relapse?
Symptoms of relapsed multiple myeloma include things like:
- Bleeding.
- Bruising.
- Tiredness.
- Weakness.
- Infections.
- Bone pain.
How quickly does myeloma progress?
How quickly multiple myeloma progresses can vary between people. An older 2007 study of 276 people found that there was a 10% risk of progression in people with early multiple myeloma per year for the first 5 years of illness.
What are good numbers for multiple myeloma?
Normal range: 37-286 mg/dL Your body produces IgM antibodies to help the immune system fight infections.