How is the genome configured within influenza viruses?
The influenza viruses are characterized by segmented, negative-strand RNA genomes requiring an RNA-dependent RNA polymerase of viral origin for replication. The particular structure of the influenza virus genome and function of its viral proteins enable antigenic drift and antigenic shift.
What is unusual about the genome of influenza virus?
Unusually for a virus, though, the influenza type A virus genome is not a single piece of RNA; instead, it consists of segmented pieces of negative-sense RNA, each piece containing either one or two genes which code for a gene product (protein).
Does influenza integrate into genome?
Unlike HIV, the viral RNA does not integrate within the host’s genome, so infections are acute rather than chronic. When messenger RNAs generated from the viral genome in the nucleus pass into the cytoplasm, the viral proteins can then be synthesized using the cell’s own ribosomes or protein-making machinery60.
Is influenza B RNA or DNA?
RNA
Genome structure and genetics The Influenza B virus genome is 14,548 nucleotides long and consists of eight segments of linear negative-sense, single-stranded RNA. The multipartite genome is encapsidated, each segment in a separate nucleocapsid, and the nucleocapsids are surrounded by one envelope.
Which is worse influenza A or B?
Type A influenza is generally considered worse than type B influenza. This is because the symptoms are often more severe in type A influenza than in type B influenza. Type A influenza is more common than type B influenza. Researchers suggest that most adults have considerable immunity against type B influenza.
Is influenza lytic or lysogenic?
lytic infection
THE OUTCOME OF VIRAL INFECTION (1) The cell may lyse or be destroyed. This is usually called a lytic infection and this type of infection is seen with influenza and polio.
Is flu virus A RNA virus?
Coronaviruses and influenza viruses are both enveloped, single-stranded RNA viruses, and both are encapsidated by nucleoprotein. However, the genomes of these 2 viruses differ in polarity and segmentation. Influenza virus is comprised of 8 single-stranded, negative-sense, viral RNA segments.
What is RNA genome?
The RNA genome is the template for synthesis of additional RNA strands (a molecule of RNA is the template and molecules of RNA are produced). During replication of RNA viruses, there are at least three types of RNA that must be synthesized: the genome, a copy of the genome (copy genome), and mRNAs.
Is the flu a lytic virus?
As a lytic virus, numerous influenza virus particles are released from the infected epithelia and macrophages (5, 9, 33).